GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.770 GeneticVariation BEFREE TWAS found locus chr2q23.3 (rs1260326) was highly pleiotropic among RHR, cardiometabolic traits, and T2D, and identified 7 genes (SMARCAD1, RP11-53O19.3, CTC-498M16.4, PDE8B, AKTIP, KDM4B, and TSHZ3) that were statistically independent and shared between RHR and T2D in tissues from the nervous and cardiovascular systems. 31648709 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		T 0.800 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.800 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		0.800 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011847
Disease:
Diabetes 		T 0.700 GeneticVariation GWASCAT Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 31511532 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011849
Disease:
Diabetes Mellitus 		T 0.700 GeneticVariation GWASCAT Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 31511532 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.800 GeneticVariation GWASCAT Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. 31451708 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0337443
Disease:
Sodium measurement 		T 0.700 GeneticVariation GWASCAT GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits. 31409800 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease 		0.760 GeneticVariation BEFREE Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD. 31255630 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs780093
rs780093
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019